APC polyclonal antibody
产品名称： APC polyclonal antibody
英文名称： APC polyclonal antibody
产品编号： PAB18087
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of APC.
- Immunogen:
- A synthetic peptide corresponding to human APC.
- Host:
- Rabbit
- Reactivity:
- Human
- Specificity:
- This antibody is specific to APC.
- Form:
- Liquid
- Storage Buffer:
- In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Immunohistochemistry (1:50~1:100)
ELISA (1:40000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Truncated APC regulates the transcriptional activity of beta-catenin in a cell cycle dependent manner.
Schneikert J, Grohmann A, Behrens J.Hum Mol Genet. 2007 Jan 15;16(2):199-209. Epub 2006 Dec 22.
- 2.
- Class II MHC/peptide complexes are released from APC and are acquired by T cell responders during specific antigen recognition.
Patel DM, Arnold PY, White GA, Nardella JP, Mannie MD.J Immunol. 1999 Nov 15;163(10):5201-10.
- 3.
- Colossal crypts bordering colon adenomas in Apc(Min) mice express full-length Apc.
Bjerknes M, Cheng H.Am J Pathol. 1999 Jun;154(6):1831-4.
- 4.
- AOM-induced mouse colon tumors do not express full-length APC protein.
Maltzman T, Whittington J, Driggers L, Stephens J, Ahnen D.Carcinogenesis. 1997 Dec;18(12):2435-9.
- Application Image
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- enlarge
- Immunohistochemistry
- ELISA
- Entrez GeneID:
- 324
- Protein Accession#:
- P25054
- Gene Name:
- APC
- Gene Alias:
- BTPS2,DP2,DP2.5,DP3,GS
- Gene Description:
- adenomatous polyposis coli
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq
- Other Designations:
- adenomatosis polyposis coli tumor suppressor
- Interactome
- Related Disease
- Adenocarcinoma
- Adenoma
- Adenomatous Polyposis Coli
- Adenomatous Polyps
- Autistic Disorder
- Barrett Esophagus
- Bone Neoplasms
- Breast cancer
- Breast Neoplasms
- Carcinoma
- Carcinoma, Large Cell
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Small Cell
- Carcinoma, Squamous Cell
- Cardiovascular Diseases
- Cell Transformation, Neoplastic
- Chromosomal Instability
- Chromosome Aberrations
- Chromosome Deletion